Title:
ヒストン脱アセチル化酵素阻害剤としてのN-ヒドロキシ-ナフタレンジカルボキサミド及びN-ヒドロキシ-ビフェニル-ジカルボキサミド化合物
Document Type and Number:
Japanese Patent JP2010540630
Kind Code:
A
Abstract:
The present invention relates to a novel class of N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide derivatives. The N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds can be used to treat cancer. The N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide derivatives in vivo.
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Inventors:
Qatar, Solomon
Mirror, thomas, a
Otte, Karin, M
Siri fibern, fen
Sardi, laura
Tempest, Paul
Zabi Lek, Anna, A
Mirror, thomas, a
Otte, Karin, M
Siri fibern, fen
Sardi, laura
Tempest, Paul
Zabi Lek, Anna, A
Application Number:
JP2010527961A
Publication Date:
December 24, 2010
Filing Date:
September 30, 2008
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07C259/10; A61K31/166; A61K31/167; A61K31/341; A61K31/343; A61K31/357; A61K31/40; A61K31/402; A61K31/416; A61K31/417; A61K31/42; A61K31/426; A61K31/427; A61K31/437; A61K31/4406; A61K31/4436; A61K31/5375; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D207/09; C07D207/325; C07D213/40; C07D213/75; C07D231/54; C07D233/64; C07D261/08; C07D265/36; C07D277/28; C07D295/12; C07D307/14; C07D307/52; C07D307/79; C07D319/16; C07D409/04; C07D417/04; C07D471/04
Attorney, Agent or Firm:
Yokoyama Isao