Title:
N,O-アミドマロネート白金錯体
Document Type and Number:
Japanese Patent JP5025062
Kind Code:
B2
Abstract:
The present invention relates to purified platinum complexes in which platinum is coordinated to form a single N,O- or O,O-chelate of an amidomalonate. The chelates, and pharmaceutically acceptable formulations thereof, are useful for the treatment of cancer. The platinum chelates may additionally be linked to one or more functional groups which increases water solubility and/or assists in tumor targeting of the chelate. Examples of tumor targeting moieties include polymers, in which one or more platinum chelates are attached to the polymer backbone via linkers capable of being cleaved in the body, and molecules with a high affinity for receptors which are concentrated or upregulated in tumor tissue and/or the tumor vasculature.
Inventors:
Stewart, Donald Earl.
Rice, John Earl.
Saint. John, John Buoy.
Rice, John Earl.
Saint. John, John Buoy.
Application Number:
JP2001550236A
Publication Date:
September 12, 2012
Filing Date:
January 04, 2001
Export Citation:
Assignee:
Access Pharmaceuticals, Incorporated
International Classes:
A61K9/08; A61K31/555; A61K47/48; A61P35/00; A61P43/00; C07C233/47; C07F15/00; C08F8/42; C08F30/04; C08G69/48; C08L43/00
Domestic Patent References:
| JPS63284134A | 1988-11-21 | |||
| JPS6494A | 1989-01-05 |
Foreign References:
| WO1998047537A1 | 1998-10-29 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita