Title:
固形腫瘍の治療用のa5b1アンタゴニストとしてのN-(ベンゾイル)-O-[2-(ピリジン-2-イルアミノ)エチル]-L-チロシン誘導体と関連化合物
Document Type and Number:
Japanese Patent JP2009539815
Kind Code:
A
Abstract:
The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to a5b1 antagonists that also exhibit appropriate selectivity profile(s) against other integrins.
Inventors:
Arnold, Jean-Claude
Drovely, Benedict
Ducré, Richard
Lambert-Van der Brempt, Christine Marie Paul
Drovely, Benedict
Ducré, Richard
Lambert-Van der Brempt, Christine Marie Paul
Application Number:
JP2009513746A
Publication Date:
November 19, 2009
Filing Date:
May 10, 2007
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D213/74; A61K31/44; A61K31/4402; A61K31/4427; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/47; A61K31/4985; A61K31/5377; A61K31/5383; A61K31/55; A61P35/00; A61P43/00; C07D213/73; C07D213/75; C07D215/38; C07D401/06; C07D401/12; C07D409/06; C07D471/04; C07D498/04
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura