Title:
N-グアニジノアルキルアミド、その製造、その使用およびそれを含む医薬調製物
Document Type and Number:
Japanese Patent JP4658430
Kind Code:
B2
Abstract:
The present invention relates to compounds of the formula I, in which A, L, Y and k have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa and/or factor VIIa and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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Inventors:
Otomar Klingler
Gerhard zohler
Elizabeth Defosa
Fahd Al-Obaydi
Armin Walther
James austrem
Gerhard zohler
Elizabeth Defosa
Fahd Al-Obaydi
Armin Walther
James austrem
Application Number:
JP2001534764A
Publication Date:
March 23, 2011
Filing Date:
October 21, 2000
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07C279/14; A61K31/155; A61K31/16; A61K31/166; A61K31/167; A61K31/197; A61K31/198; A61K31/223; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/47; A61K31/505; A61P7/02; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07C277/08; C07D213/30; C07D213/40; C07D215/48; C07D233/96; C07D239/28
Domestic Patent References:
| JP2002543130A |
Foreign References:
| US5525623 | ||||
| WO1999037643A1 | ||||
| WO1999010316A1 | ||||
| WO1996016940A1 |
Other References:
Journal of Antibiotics,1992年,45(7),p.1088-1095
Attorney, Agent or Firm:
Junji Yuda
Chika Takagi
Kosuke Nishimura
Chika Takagi
Kosuke Nishimura