N-HETEROCYCLIC COMPOUND USEFUL AS JAK INHIBITOR

Japanese Patent JP2014024867

A

To provide compounds useful as inhibitors of protein kinases.

The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders, cardiac disorders, neurodegenerative disorders, autoimmune disorders, conditions associated with organ transplantation, inflammatory disorders, or immunologically mediated disorders in a patient.

WANNAMAKER MARION
SALITURO FRANCESCO
PIERCE ALBERT
ALEXANDER ARONOV
MARTINEZ-BOTELLA GABRIEL
WANG JIAN
FARMER LUC
LEDEBOER MARK
WANG TIANSHENG
BETHIEL RANDY
LEDFORD BRIAN
EMILIE PORTER

JP2013228193A

February 06, 2014

November 01, 2013

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VERTEX PHARMA

C07D239/42; A61K31/505; A61K31/506; A61K31/5377; A61P1/16; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D405/04; C07D405/14; C07D417/04; C07D417/14

Hidesaku Yamamoto
Natsuki Morishita

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