Title:
N,N’-置換-1,3-ジアミノ-2-ヒドロキシプロパン誘導体
Document Type and Number:
Japanese Patent JP2005520791
Kind Code:
A
Abstract:
Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.
Inventors:
John, Barges
Milard, michael
Jagod Zinska, Barbara
Beck, James, Pee.
Gailnas, Andrea
Fan, rally
Sealy, Jennifer
Templink, loose
Frescos, John
Mickelson, John
Samara, Luxman
Hom, Roy
Milard, michael
Jagod Zinska, Barbara
Beck, James, Pee.
Gailnas, Andrea
Fan, rally
Sealy, Jennifer
Templink, loose
Frescos, John
Mickelson, John
Samara, Luxman
Hom, Roy
Application Number:
JP2003542142A
Publication Date:
July 14, 2005
Filing Date:
November 08, 2002
Export Citation:
Assignee:
PHARMACIA & UPJOHN COMPANY
Pharmacia & Up John Company LRC
Pharmacia & Up John Company LRC
International Classes:
A61K31/164; A61K31/18; A61K31/27; A61K31/336; A61K31/341; A61K31/357; A61K31/36; A61K31/381; A61K31/39; A61K31/40; A61K31/41; A61K31/415; A61K31/416; A61K31/4164; A61K31/421; A61K31/423; A61K31/426; A61K31/427; A61K31/428; A61K31/437; A61K31/439; A61K31/4402; A61K31/4409; A61K31/4418; A61K31/4439; A61K31/445; A61K31/455; A61K31/47; A61K31/495; A61P25/28; A61P43/00; C07C217/58; C07C233/36; C07C233/40; C07C233/58; C07C233/78; C07C235/20; C07C235/50; C07C235/74; C07C237/04; C07C237/06; C07C237/08; C07C237/22; C07C237/42; C07C251/38; C07C255/58; C07C271/28; C07C271/44; C07C311/08; C07C311/16; C07C311/17; C07C311/18; C07C311/19; C07C311/20; C07C311/21; C07C311/29; C07C311/37; C07C317/44; C07C317/46; C07C317/50; C07C323/60; C07C323/62; C07C323/65; C07D207/06; C07D207/08; C07D207/14; C07D207/26; C07D207/267; C07D207/27; C07D207/48; C07D209/08; C07D209/42; C07D211/10; C07D211/44; C07D211/58; C07D211/60; C07D211/96; C07D213/36; C07D213/56; C07D213/64; C07D213/71; C07D213/80; C07D213/81; C07D213/82; C07D213/85; C07D213/89; C07D215/36; C07D215/42; C07D215/48; C07D215/54; C07D215/56; C07D217/08; C07D217/22; C07D223/10; C07D231/14; C07D231/38; C07D231/56; C07D233/64; C07D233/84; C07D233/90; C07D237/14; C07D239/28; C07D239/34; C07D239/42; C07D239/48; C07D241/08; C07D241/20; C07D241/24; C07D241/44; C07D243/08; C07D249/06; C07D249/10; C07D251/46; C07D251/54; C07D257/04; C07D257/06; C07D261/08; C07D261/14; C07D261/18; C07D263/06; C07D263/32; C07D263/34; C07D263/48; C07D263/54; C07D263/56; C07D263/58; C07D265/36; C07D295/16; C07D271/06; C07D271/08; C07D271/12; C07D275/06; C07D277/20; C07D277/30; C07D277/36; C07D277/56; C07D277/68; C07D277/82; C07D279/08; C07D279/16; C07D285/06; C07D285/10; C07D285/135; C07D295/155; C07D295/185; C07D295/192; C07D295/22; C07D295/26; C07D303/36; C07D307/20; C07D307/46; C07D307/52; C07D307/68; C07D307/84; C07D307/86; C07D307/91; C07D309/12; C07D311/04; C07D311/58; C07D317/68; C07D319/18; C07D327/06; C07D333/20; C07D333/22; C07D333/32; C07D333/34; C07D333/38; C07D333/58; C07D333/62; C07D333/68; C07D333/72; C07D335/06; C07D401/04; C07D403/04; C07D405/12; C07D409/04; C07D411/12; C07D413/04; C07D413/06; C07D413/12; C07D417/04; C07D417/12; C07D453/02; C07D471/04; C07D473/06; C07D473/08; C07D473/16; C07D487/04; C07D495/04; C07D498/04; C07D285/12; C07D; (IPC1-7): C07C217/58; A61K31/137; A61K31/164; A61K31/166; A61K31/18; A61K31/22; A61K31/27; A61K31/336; A61K31/341; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/39; A61K31/40; A61K31/4025; A61K31/404; A61K31/41; A61K31/415; A61K31/416; A61K31/4162; A61K31/4164; A61K31/4178; A61K31/421; A61K31/423; A61K31/426; A61K31/427; A61K31/428; A61K31/437; A61K31/439; A61K31/4402; A61K31/4409; A61K31/4418; A61K31/4439; A61K31/445; A61K31/455; A61K31/47; A61K31/495; A61K31/496; A61K31/505; A61K31/506; A61K31/538; A61K31/54; A61K31/55; A61P25/28; A61P43/00; C07C233/78; C07C233/83; C07C235/10; C07C237/06; C07C237/22; C07C251/38; C07C271/16; C07C271/18; C07C311/18; C07C311/29; C07C311/46; C07C317/14; C07C317/44; C07C323/60; C07D207/06; C07D207/08; C07D207/14; C07D207/26; C07D207/277; C07D207/48; C07D209/08; C07D211/10; C07D211/44; C07D213/36; C07D213/42; C07D213/56; C07D213/64; C07D213/81; C07D213/82; C07D213/89; C07D215/54; C07D217/08; C07D217/22; C07D223/10; C07D231/14; C07D231/56; C07D233/64; C07D233/84; C07D233/90; C07D239/34; C07D239/48; C07D241/08; C07D241/24; C07D261/08; C07D261/18; C07D263/06; C07D263/20; C07D263/34; C07D263/56; C07D265/36; C07D271/06; C07D271/12; C07D275/06; C07D277/20; C07D277/30; C07D277/56; C07D279/08; C07D279/16; C07D285/06; C07D295/16; C07D295/22; C07D303/36; C07D307/20; C07D307/52; C07D309/12; C07D311/58; C07D317/68; C07D319/18; C07D327/06; C07D333/20; C07D333/58; C07D333/72; C07D335/06; C07D403/04; C07D413/04; C07D413/06; C07D413/12; C07D417/04; C07D417/12; C07D453/02; C07D471/04; C07D495/04
Domestic Patent References:
| JPH06502860A | 1994-03-31 | |||
| JP2004502669A | 2004-01-29 |
Foreign References:
| US5783701A | 1998-07-21 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda