Title:
N-SUBSTITUTED ALKYL-N'-ALKYLAMINOALKYL UREA DERIVATIVE
Document Type and Number:
Japanese Patent JPS6434952
Kind Code:
A
Abstract:
NEW MATERIAL: A compd. of formula I [where Ar is naphthyl,2-pyridinyl, phenyl,2 -furanylmethyl, etc.; X is S, SO, SO2 or O; (d) is O or 1: B is carbonyl or thioxomethyl; (n), (m) and (p) are 2-6: one of Z and W is R and the other is (CH2)m-NR1R2; each of R and R1-R4 is H, a lower alkyl, a cycloalkyl or a (substd.) pyhenyl] or its salt.
EXAMPLE: N'-[2 -(diethylamino) ethyl] -N-[3 -(diethylamino) propyl] -N-[2 -(phenylsulfonyl) ethyl]urea.
USE: An antiarrhythmic agent.
PROCESS: A compd. of formula Ia is obtd. by allowing a compd. of formula V to react with an alkyldiamine of formula IV in the presence of a proper org. solvent such as acetonitrile and allowing the resultant product to react with a compd. of formula III (where Y is O or S).
Inventors:
JIEEMUSU ROBAATO SHIYANKURIN J
Application Number:
JP7172488A
Publication Date:
February 06, 1989
Filing Date:
March 25, 1988
Export Citation:
Assignee:
ROBINS CO INC A H
International Classes:
A61K31/00; A61K31/275; A61K31/34; A61K31/341; A61P9/06; C07C67/00; C07C239/00; C07C275/14; C07C275/24; C07C279/28; C07C313/00; C07C317/28; C07C317/32; C07C317/36; C07C317/40; A61K31/17; C07C317/42; C07C317/44; C07C323/20; C07C323/44; C07C323/65; C07C335/08; C07D213/40; C07D213/64; C07D213/70; C07D213/71; C07D295/13; C07D307/38; C07D307/40; (IPC1-7): A61K31/00; A61K31/17; A61K31/275; A61K31/34; C07C127/15; C07C129/12; C07C145/00; C07C147/06; C07C147/14; C07C149/42; C07D213/64; C07D213/70; C07D213/71; C07D307/38; C07D307/40
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)