Title:
N-SUBSTITUTED BENZAMIDE AND USE THEREOF FOR TREATMENT OF PAIN
Document Type and Number:
Japanese Patent JP2017057206
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method of treating pain of mammalian.SOLUTION: There is provided a novel compound having the general formula (I), where variable R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave meanings described in the specification, a pharmaceutically acceptable salt thereof, a composition containing such compound and a method for using the compound and the composition. In other aspect, there is provided a method for treating pain of mammalian by inhibition of ion flux passing potential-dependent sodium channel in the mammalian including administering therapeutically effective amount of the compound of the formula I or the pharmaceutically acceptable salt to mammalian who needs the same.SELECTED DRAWING: None
Inventors:
JEAN-CHRISTOPHE ANDREZ
SULTAN CHOWDHURY
SHANNON DECKER
CHRISTOPH MARTIN DEHNHARDT
THILO FOCKEN
MICHAEL EDWARD GRIMWOOD
IVAN WILLIAM HEMEON
QI JIA
LI JUN
DANIEL F ORTWINE
SAFINA BRIAN
SHENG TAO
SHAOYI SUN
DANIEL P SUTHERLIN
MICHAEL SCOTT WILSON
ALLA YUREVNA ZENOVA
SULTAN CHOWDHURY
SHANNON DECKER
CHRISTOPH MARTIN DEHNHARDT
THILO FOCKEN
MICHAEL EDWARD GRIMWOOD
IVAN WILLIAM HEMEON
QI JIA
LI JUN
DANIEL F ORTWINE
SAFINA BRIAN
SHENG TAO
SHAOYI SUN
DANIEL P SUTHERLIN
MICHAEL SCOTT WILSON
ALLA YUREVNA ZENOVA
Application Number:
JP2016214208A
Publication Date:
March 23, 2017
Filing Date:
November 01, 2016
Export Citation:
Assignee:
GENENTECH INC
XENON PHARMACEUTICALS INC
XENON PHARMACEUTICALS INC
International Classes:
C07C307/06; A61K31/18; A61K31/216; A61K31/275; A61K31/341; A61K31/351; A61K31/353; A61K31/397; A61K31/40; A61K31/41; A61K31/4164; A61K31/438; A61K31/439; A61K31/44; A61K31/4427; A61K31/445; A61K31/465; A61K31/496; A61K31/5375; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P13/10; A61P17/04; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P29/00; A61P35/00; A61P43/00; C07C311/51; C07D205/04; C07D207/48; C07D211/22; C07D211/44; C07D211/96; C07D213/64; C07D213/82; C07D233/84; C07D257/04; C07D295/185; C07D295/26; C07D307/18; C07D309/08; C07D311/04; C07D401/12; C07D405/12; C07D451/02; C07D471/08; C07D491/107; C07D491/20
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita