Title:
ORL-1受容体リガンドとしてのN置換スピロピペリジン化合物
Document Type and Number:
Japanese Patent JP2005519921
Kind Code:
A
Abstract:
A compound of the formula:or a pharmaceutically acceptable salt, ester or ether thereof, wherein R<1 >through R<12 >are independently hydrogen or the like; X<1 >and X<2 >are independently CH2 or the like; R<13 >is hydrogen or the like; or R<12 >and R<13 >taken together with three ring atoms of the quinoline ring separating said substituents form a heterocyclic ring; R<14 >and R<15 >are hydrogen or the like or these groups taken together form oxo; and the dotted line represents a single or double bond. These compounds are ligands for ORL-1 receptor and especially are antagonists for said receptor.
Inventors:
Fumitaka Ito
Hiroki Koike
Morita Ari
Hiroki Koike
Morita Ari
Application Number:
JP2003564048A
Publication Date:
July 07, 2005
Filing Date:
January 16, 2003
Export Citation:
Assignee:
Pfizer Japan Inc
International Classes:
C07D491/107; A61K31/4709; A61K31/4745; A61K31/5365; A61K31/5383; A61P1/16; A61P3/04; A61P9/00; A61P9/02; A61P11/00; A61P13/12; A61P15/00; A61P25/00; A61P25/04; A61P25/08; A61P25/16; A61P25/22; A61P25/28; A61P25/36; A61P37/00; A61P43/00; C07D401/06; C07D471/06; C07D471/10; C07D487/06; C07D487/10; C07D491/10; C07D498/06; (IPC1-7): C07D401/06; A61K31/4709; A61K31/4745; A61K31/5365; A61K31/5383; A61P1/16; A61P3/04; A61P9/00; A61P9/02; A61P11/00; A61P13/12; A61P15/00; A61P25/00; A61P25/04; A61P25/08; A61P25/16; A61P25/22; A61P25/28; A61P25/36; A61P37/00; A61P43/00; C07D471/06; C07D471/10; C07D491/107; C07D498/06
Attorney, Agent or Firm:
Yoshinobu Murofushi