Title:
N-sulfo nil-ized tetrahydroquinoline, 2 related ring compounds, and the sick medical treatment for prevention of RORgamma activity
Document Type and Number:
Japanese Patent JP6063870
Kind Code:
B2
Abstract:
The invention provides tetrahydroquinoline and related compounds, pharmaceutical compositions, methods of inhibiting RORγ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydroquinoline and related compounds are provided.
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Inventors:
Gryk, Gary Day
Tougtood, Peter El
Romero, Arthur, Glenn
Banhi Yuis, Cyad A
Aichia, Thomas, Daniel
Curls
Matson, Machine N
Thomas, William Debited
Stein, Karin, Anne
Claw-The Espersen, Eric
Wang, Jiang
Tougtood, Peter El
Romero, Arthur, Glenn
Banhi Yuis, Cyad A
Aichia, Thomas, Daniel
Curls
Matson, Machine N
Thomas, William Debited
Stein, Karin, Anne
Claw-The Espersen, Eric
Wang, Jiang
Application Number:
JP2013537929A
Publication Date:
January 18, 2017
Filing Date:
November 08, 2011
Export Citation:
Assignee:
Lycera Corporation
International Classes:
C07D265/36; A61K31/538; A61P1/04; A61P1/16; A61P3/10; A61P7/02; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P37/06; A61P37/08; A61P43/00; C07D413/12
Domestic Patent References:
| JP2004307487A | ||||
| JP2007509140A | ||||
| JP2009541461A | ||||
| JP2009506047A | ||||
| JP6500122A | ||||
| JP2009538910A | ||||
| JP2000159749A | ||||
| JP2000509719A | ||||
| JP2006512356A | ||||
| JP2009526800A |
Foreign References:
| WO2009032667A1 | ||||
| WO2009147187A1 | ||||
| WO2010059602A1 | ||||
| WO2010102958A1 | ||||
| WO2010125082A1 | ||||
| US6348032 | ||||
| WO2009035997A1 | ||||
| WO2007138998A1 | ||||
| WO2008045664A1 | ||||
| WO2010123139A1 | ||||
| WO2010049144A1 |
Other References:
NICOLAS GUIMOND,RHODIUM(III)-CATALYZED ISOQUINOLONE SYNTHESIS: THE N-O BOND AS A HANDLE 以下備考,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,AMERICAN CHEMICAL SOCIETY,2010年 5月26日,V132 N20,P6908-6909,FOR C-N BOND FORMATION AND CATALYST TURNOVER
YEH VINCE S C,PRACTICAL CU-CATALYZED AMINATION OF FUNCTIONALIZED HETEROARYL HALIDES,TETRAHEDRON LETTERS,NL,ELSEVIER,2006年 8月21日,V47 N34,P6011-6016
BIAO JIANG,SYNTHESIS AND CYTOTOXICITY EVALUATION OF NOVEL INDOLYLPYRIMIDINES AND INDOLYLPYRAZINES 以下備考,BIOORGANIC & MEDICINAL CHEMISTRY,英国,PERGAMON,2001年 1月 1日,V9,P1149-1154,AS POTENTIAL ANTITUMOR AGENTS
MASAYUKI MURASE,A NEW CONCISE SYNTHESIS OF ARCYRIACYANIN A AND ITS UNIQUE INHIBITORY ACTIVITY 以下備考,CHEMICAL & PHARMACEUTICAL BULLETIN,2000年 1月 1日,V48 N1,P81-84,AGAINST A PANEL OF HUMAN CANCER CELL LINE
BOGER DALE L,REGIOCONTROLLED NUCLEOPHILIC ADDITION TO SELECTIVELY ACTIVATED P-QUINONE DIIMINES: 以下備考,JOURNAL OF ORGANIC CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1990年 1月 1日,V55 N4,P1379-1390,ALTERNATIVE PREPARATION OF A KEY INTERMEDIATE EMPLOYED IN THE PREPARATION 以下省略
MINORU ISHIKURA,AN EFFICIENT SYNTHESIS OF 3-HETEROARYLPYRIDINES VIA DIETHYL-(3-PYRIDYL)-BORANE,SYNTHESIS [ONLINE],1984年 1月 1日,P936-938,URL,http://www.thieme-connect.de/ejournals/pdf/synthesis/doi/10.1055/s-1984-31026.pdf
YEH VINCE S C,PRACTICAL CU-CATALYZED AMINATION OF FUNCTIONALIZED HETEROARYL HALIDES,TETRAHEDRON LETTERS,NL,ELSEVIER,2006年 8月21日,V47 N34,P6011-6016
BIAO JIANG,SYNTHESIS AND CYTOTOXICITY EVALUATION OF NOVEL INDOLYLPYRIMIDINES AND INDOLYLPYRAZINES 以下備考,BIOORGANIC & MEDICINAL CHEMISTRY,英国,PERGAMON,2001年 1月 1日,V9,P1149-1154,AS POTENTIAL ANTITUMOR AGENTS
MASAYUKI MURASE,A NEW CONCISE SYNTHESIS OF ARCYRIACYANIN A AND ITS UNIQUE INHIBITORY ACTIVITY 以下備考,CHEMICAL & PHARMACEUTICAL BULLETIN,2000年 1月 1日,V48 N1,P81-84,AGAINST A PANEL OF HUMAN CANCER CELL LINE
BOGER DALE L,REGIOCONTROLLED NUCLEOPHILIC ADDITION TO SELECTIVELY ACTIVATED P-QUINONE DIIMINES: 以下備考,JOURNAL OF ORGANIC CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1990年 1月 1日,V55 N4,P1379-1390,ALTERNATIVE PREPARATION OF A KEY INTERMEDIATE EMPLOYED IN THE PREPARATION 以下省略
MINORU ISHIKURA,AN EFFICIENT SYNTHESIS OF 3-HETEROARYLPYRIDINES VIA DIETHYL-(3-PYRIDYL)-BORANE,SYNTHESIS [ONLINE],1984年 1月 1日,P936-938,URL,http://www.thieme-connect.de/ejournals/pdf/synthesis/doi/10.1055/s-1984-31026.pdf
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Yasufumi Shiroyama