Title:
オリゴヌクレオチド・ハイブリダイゼーションにユニバーサル・ヌクレオシドとして使用されるN8-及びC8-連結プリン塩基、並びに構造的に関連したヘテロ環
Document Type and Number:
Japanese Patent JP4130545
Kind Code:
B2
Abstract:
The present invention is directed to a nucleic acid binding compound comprising N<8>- or C<8>-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
Inventors:
Sarah, Frank
Develack, halalt
Frank Mang, Frank
Heindle, Dieter
Von derreltz, herbert
Develack, halalt
Frank Mang, Frank
Heindle, Dieter
Von derreltz, herbert
Application Number:
JP2001571695A
Publication Date:
August 06, 2008
Filing Date:
March 27, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07H21/04; C12N15/09; A61K31/70; C07H19/04; C07H19/10; C07H19/16; C07H19/20; C07H19/23; C07H21/00; C12Q1/68
Domestic Patent References:
| JP8003186A |
Other References:
Helvetica Chimica Acta,1992年,Vol.75,p.1885-1896
Helvetica Chimica Acta,1994年,Vol.77,p.1003-1017
J.Am.Chem.Soc.,1992年,Vol.114, No.4,p.1470-1478
Helvetica Chimica Acta,1989年,Vol.72,p.868-881
Helvetica Chimica Acta,1988年,Vol.71,p.1813-1823
Biochemistry,1976年,Vol.15, No.5,p.1005-1015
Helvetica Chimica Acta,1994年,Vol.77,p.1003-1017
J.Am.Chem.Soc.,1992年,Vol.114, No.4,p.1470-1478
Helvetica Chimica Acta,1989年,Vol.72,p.868-881
Helvetica Chimica Acta,1988年,Vol.71,p.1813-1823
Biochemistry,1976年,Vol.15, No.5,p.1005-1015
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei