Title:
NP-1アンタゴニストおよびそれらの治療上の使用
Document Type and Number:
Japanese Patent JP2013503146
Kind Code:
A
Abstract:
Compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein: W is arylene, heteroarylene or formula (a) each L is independently alkylene, alkenylene, alkynylene, a direct bond, arylene, cycloalkylene, alkylene-arylene, alkylene-C═O or —C═O; each X is independently an N-containing heteroarylene, N-containing cycloalkylene or NR; Y is N-containing heteroaryl, N-containing cycloalkyl, NR2, OR1, CN or CO2R; Z1 is formula (b); are useful in therapy, particularly in the therapy of neurodegeneration and cancer.
Inventors:
Melanie Jane Croshaw
Philip Spencer Fallon
Ashley Nicholas Jarvis
Jonathan Raymond Powell
Natalie Louise Winfield
David Sellwood
Ian Charles Zachary
Haiyan Zia
Philip Spencer Fallon
Ashley Nicholas Jarvis
Jonathan Raymond Powell
Natalie Louise Winfield
David Sellwood
Ian Charles Zachary
Haiyan Zia
Application Number:
JP2012526129A
Publication Date:
January 31, 2013
Filing Date:
August 25, 2010
Export Citation:
Assignee:
Ark Therapeutics Limited
International Classes:
C07D333/38; A61K31/381; A61K31/4155; A61K31/4178; A61K31/422; A61K31/4245; A61K31/427; A61K31/4436; A61K31/4439; A61K31/4535; A61K31/454; A61K31/496; A61K31/497; A61K31/53; A61K31/5377; A61K49/00; A61K51/00; A61P1/16; A61P3/10; A61P7/02; A61P9/04; A61P17/06; A61P25/00; A61P25/28; A61P27/02; A61P27/06; A61P31/12; A61P35/00; A61P35/02; A61P37/02; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14
Foreign References:
| WO2008040979A1 | 2008-04-10 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto