Title:
NRPS-PKS遺伝子群ならびにその操作および有用性
Document Type and Number:
Japanese Patent JP2011515086
Kind Code:
A
Abstract:
A nucleic acid molecule comprises a nucleotide sequence: as shown in SEQ ID No. 1, which is the complement of SEQ ID No. 1, which is degenerate with SEQ ID No. 1, or which has at least 85% sequence identity with SEQ ID No. 1, or which is a part of such a sequence. The nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. The nucleic acid molecule may be used to prepare a modified BE-14106 biosynthetic gene cluster for the preparation of a modified BE-14106 molecule.
Inventors:
Zotoshev, Sergey
Anna Jorgensen
Shretta, Hubbard
Ellingsen, Tronde, Erling
Faervic, Espen
Degnes, Christine, Frogstud
Clinkenburg, Gail
Bruheim, Par
Anna Jorgensen
Shretta, Hubbard
Ellingsen, Tronde, Erling
Faervic, Espen
Degnes, Christine, Frogstud
Clinkenburg, Gail
Bruheim, Par
Application Number:
JP2011500293A
Publication Date:
May 19, 2011
Filing Date:
March 20, 2009
Export Citation:
Assignee:
SINVENT AS
International Classes:
C12N15/09; C07K14/36; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C07D225/02
Domestic Patent References:
| JPH041179A | 1992-01-06 |
Other References:
JPN6013007195; Ｅｎｖｉｒｏｎ．Ｍｉｃｒｏｂｉｏｌ．，Ｖｏｌ．９，Ｎｏ．１１（２００７）ｐ．２７５６-２７６４
JPN6013007197; Ｊ．Ａｎｔｉｂｉｏｔ．，Ｖｏｌ．４５，Ｎｏ．６（１９９２）ｐ．８６８-８７４
JPN6013007199; Ｊ．Ｎａｔ．Ｐｒｏｄ．，Ｖｏｌ．６７（２００４）ｐ．１４００-１４０２
JPN6013007201; Ｃｈｅｍ．Ｒｅｖ．，Ｖｏｌ．９７（１９９７）ｐ．２５５７-２５７５
JPN6013007197; Ｊ．Ａｎｔｉｂｉｏｔ．，Ｖｏｌ．４５，Ｎｏ．６（１９９２）ｐ．８６８-８７４
JPN6013007199; Ｊ．Ｎａｔ．Ｐｒｏｄ．，Ｖｏｌ．６７（２００４）ｐ．１４００-１４０２
JPN6013007201; Ｃｈｅｍ．Ｒｅｖ．，Ｖｏｌ．９７（１９９７）ｐ．２５５７-２５７５
Attorney, Agent or Firm:
Patent corporation ssinpat