Title:
【発明の名称】エイズ及びその他のレトロウイルス病用ワクチンの遺伝子工学による製造
Document Type and Number:
Japanese Patent JP2537570
Kind Code:
B2
Abstract:
The present invention is directed toward methods for the production of non-infectious, replication-deficient, immunogenic human immunodeficiency virus (HIV)-like particles. These particles are prepared from a recombinant expression vector comprising a heterologous promoter operatively connected to a DNA molecule comprising a modified HIV genome devoid of the long terminal repeat (LTR) regulatory regions but containing at least the gag and pol genes in their natural genomic arrangement. This vector is introduced into mammalian cells to produce the particles of interest. These particles should prove useful in a number of diagnostic, virologic, and immunologic applications.
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Inventors:
HAINESU JOERU
KURAIN MAIKERU HENRII
ROINSUKII BENJAMIN
KAO SHII SHIIAN
KURAIN MAIKERU HENRII
ROINSUKII BENJAMIN
KAO SHII SHIIAN
Application Number:
JP51352490A
Publication Date:
September 25, 1996
Filing Date:
October 12, 1990
Export Citation:
Assignee:
CONNAUGHT LAB
International Classes:
C12N7/00; A61K39/21; A61P31/12; C07K14/155; C07K14/16; C12N15/09; C12N15/48; C12N15/49; C12P21/00; C12P21/02; C12Q1/70; G01N33/569; A61K39/00; C12R1/91; (IPC1-7): C12N15/09; A61K39/21; C07K14/155; C12P21/00; G01N33/569
Domestic Patent References:
| JP1120284A | ||||
| JP59104325A | ||||
| JP63500985A |
Other References:
【文献】欧州特許公開335635(EP,A)
Attorney, Agent or Firm:
Wakabayashi Tadashi