Title:
PEPTIDE-LIPID DERIVATIVE AND LIPOSOME
Document Type and Number:
Japanese Patent JP2579730
Kind Code:
B2
Abstract:
PURPOSE: To provide a new peptide-lipid derivative useful as a metastasis- suppressing substance for cancer cell.
CONSTITUTION: A lipid is bonded directly or via a linker to a peptide containing a sequence composed of Arg-Gly-Asp. The total polymerization degree of the amino acids in the peptide is ≤20 and the lipid to be used for the production of the peptide-lipid derivative is preferably cholesterol and 8-18C alkyl group. The bonding of the lipid to the peptide containing the Arg-Gly-Asp sequence can be carried out e.g. by reacting an amino group or a carboxyl group of a peptide with a cholesterol derivative or an alkyl group having a functional group capable of forming a covalent bond with the functional group of the peptide. A liposome can be prepared by compounding the peptide-lipid derivative.
More Like This:
Inventors:
Toyoaki Ishikura
Jun Sasaki
Hiroshi Nagasono
Naoichi Murahashi
Takashi Kato
Kaneko Hero
Isao Tanaka
Jun Sasaki
Hiroshi Nagasono
Naoichi Murahashi
Takashi Kato
Kaneko Hero
Isao Tanaka
Application Number:
JP929093A
Publication Date:
February 12, 1997
Filing Date:
January 22, 1993
Export Citation:
Assignee:
DDS Research Institute Co., Ltd.
International Classes:
A61K9/127; A61K47/48; A61P31/04; C07K14/00; (IPC1-7): A61K47/48; A61K9/127
Domestic Patent References:
| JPH04221394A |
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)