Title:
【発明の名称】誘導化されたDTPA―錯体、これを含有する製薬学的薬剤、これを含有するNMR―及びレントゲン―診断剤及び放射線療法剤、この化合物の製法及び製薬学的薬剤の製法
Document Type and Number:
Japanese Patent JP2603357
Kind Code:
B2
Abstract:
Compounds of the general formula in which Z<1> and Z<2> each represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n(C6H4) l-(O)r-R, in which m and n denote the figures 0 - 20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an unsubstituted or OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21 - 29, 42, 44 or 57 - 83, with the proviso that at least two of the substituents X represent a metal ion equivalent in which one of the substituents Z<1> and Z<2> represents a hydrogen atom and the other does not represent a hydrogen atom, in which - if n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1, in which Z<1> or Z<2> do not represent -CH2-C6H4-O-CH2-COOCH2C6H5 or CH2-C6H4-O-(CH2)5-COOCH2C6H5 and in which -(O)r-R does not represent -OH, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.
Inventors:
Helibelt Schmidt-Wylitzhi
Johannes Pratzek
Heinz Grease
Cabriere Syuman-Giam Piri
Hubert Forakler
Hans-Joachim Vwainmann
Johannes Pratzek
Heinz Grease
Cabriere Syuman-Giam Piri
Hubert Forakler
Hans-Joachim Vwainmann
Application Number:
JP17037290A
Publication Date:
April 23, 1997
Filing Date:
June 29, 1990
Export Citation:
Assignee:
SCHERING AKTIENGESELLSCHAFT
International Classes:
A61K49/04; A61K49/06; C07C227/18; C07C229/16; C07C229/76; A61K49/00; C07F5/00; C07F9/94; C07F15/02; (IPC1-7): C07C229/16; A61K49/00; A61K49/04; C07C227/18; C07C229/76
Domestic Patent References:
| JP89000557Y |
Other References:
【文献】国際公開89/557(WO,A)
Attorney, Agent or Firm:
Toshio Yano (2 outside)