Title:
【発明の名称】少なくとも1個の分子内ジスルフィド結合を含有する蛋白質を相当する還元された組替え蛋白質を5.0以下のpHで酸化することによって製造する方法
Document Type and Number:
Japanese Patent JP3021040
Kind Code:
B2
Abstract:
PCT No. PCT/FR90/00843 Sec. 371 Date May 6, 1992 Sec. 102(e) Date May 6, 1992 PCT Filed Nov. 23, 1990 PCT Pub. No. WO92/09623 PCT Pub. Date Jun. 11, 1992.Preparation process for a protein comprising at least one intramolecular disulphide bridge, and optionally one or more additional cysteines, comprising the oxidation of the corresponding reduced recombinant protein using an oxidizing agent and characterized in that an aqueous solution of the reduced protein is reacted at a pH of less than 5.0.
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Inventors:
Abekasi, Pierre Eve
Leclerc, jack
Libron, Philip
Leclerc, jack
Libron, Philip
Application Number:
JP50096891A
Publication Date:
March 15, 2000
Filing Date:
November 23, 1990
Export Citation:
Assignee:
Hoechst Marion Roussel
International Classes:
C07K1/00; C07K1/107; C07K14/52; C07K1/113; C07K14/54; C07K14/55; C12N15/09; C12N15/26; C12P21/00; C12P21/02; (IPC1-7): C12P21/02
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)