Title:
【発明の名称】ブラジキニン拮抗作用を有するペプチド
Document Type and Number:
Japanese Patent JP2552402
Kind Code:
B2
Abstract:
Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
Inventors:
GEERUHARUTO BURAIHOORU
SHUTEFUAN HENKE
YOHEN KUNORE
BERUNUARUTO SHERUKENSU
FURANTSU HOTSUKU
SHUTEFUAN HENKE
YOHEN KUNORE
BERUNUARUTO SHERUKENSU
FURANTSU HOTSUKU
Application Number:
JP12184891A
Publication Date:
November 13, 1996
Filing Date:
April 25, 1991
Export Citation:
Assignee:
HOECHST AG
International Classes:
A61K38/08; A61K38/17; A61P29/00; A61P37/08; C07K1/02; C07K7/06; A61K38/00; C07K7/18; (IPC1-7): C07K7/06; A61K38/00; A61K38/17; C07K1/02; C07K7/18
Domestic Patent References:
| JP2184697A |
Attorney, Agent or Firm:
Chika Takagi (2 outside)