Title:
NAPHTHOTHIAZEPINONES
Document Type and Number:
Japanese Patent JPS62205067
Kind Code:
A
Abstract:
It has been found that the novel compounds of the formula
wherein R1 is phenyl substituted with 1 to 3 lower alkoxy groups or 1 to 3 halogens, R2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy,
-O- @-O-(C1-C5 alkyl) or -O-@(CH2) m-O-(C1-C3 a lkyl),
R3 and R4 are, independently, lower alkyl, phenyl lower alkyl or, taken together, form a piperidine or pyrrolidine ring, n is 2 to 4 and m is 1 to 2,
and pharmaceutically acceptable acid addition salts thereof have activity as calcium channel blockers and, accordingly, are useful as agents for treating ischemia and as agents for lowering blood pressure. They can be prepared by reacting a compound of the formula
with a compound of the formula
and optionally converting the compound thus obtained to a compound wherein R2 is other than hydroxy.
Inventors:
ERUNO MOHAKUSHI
JIEI FUIRITSUPU OBURAIEN
JIEI FUIRITSUPU OBURAIEN
Application Number:
JP4047287A
Publication Date:
September 09, 1987
Filing Date:
February 25, 1987
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/55; A61K31/554; A61P3/00; C07D281/10; A61P9/08; A61P9/10; A61P9/12; C07D281/08; (IPC1-7): A61K31/55; C07D281/10
Attorney, Agent or Firm:
Heiyoshi Odashima
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