Title:
難溶性抗けいれん剤を含む経鼻抗けいれん医薬組成物
Document Type and Number:
Japanese Patent JP5626686
Kind Code:
B2
Abstract:
There is provided a transnasal anticonvulsive pharmaceutical composition including a poorly soluble anticonvulsant. The anticonvulsive pharmaceutical composition comprising a poorly soluble anticonvulsant as an active component, which is transnasally spray-administered, comprises diethylene glycol monoethyl ether and fatty acid ester, wherein the fatty acid ester is selected from the group consisting of caprylocaproyl polyoxylglyceride, isopropyl palmitate, oleoyl polyoxylglyceride, sorbitan monolaurate 20, methyl laurate, ethyl laurate and polysorbate 20. Also, the anticonvulsive pharmaceutical composition comprising a poorly soluble anticonvulsant as an active component, which is transnasally spray-administered, comprises diethylene glycol monoethyl ether, fatty acid ester, methylpyrrolidone, water and alcohol. Therefore, the transnasal anticonvulsive pharmaceutical composition may be useful to highly enhance the bioavailability of the poorly soluble anticonvulsant. Also, the transnasal anticonvulsive pharmaceutical composition may be useful to allow the poorly soluble anticonvulsant to show the improved viscosity and/or enhanced solubility in order to effectively deliver the poorly soluble anticonvulsant at a therapeutic dose.
Inventors:
ペク、 ミョン−キ
チョ、 ジェ−フン
チャン、 ヘ−ジン
チョ、 ジェ−フン
チャン、 ヘ−ジン
Application Number:
JP2011509416A
Publication Date:
November 19, 2014
Filing Date:
May 14, 2009
Export Citation:
Assignee:
エスケー バイオファーマスティカルズ カンパニー リミテッド
International Classes:
A61K31/5513; A61K9/08; A61K9/12; A61K47/10; A61K47/14; A61K47/22; A61K47/34; A61P25/08
Attorney, Agent or Firm:
Sepal Tsuneo
Yoshio Miyazaki
Tsutomu Kato
伴 Tomoatsu
Yoshio Miyazaki
Tsutomu Kato
伴 Tomoatsu