Title:
ナチュラルキラーp30(NKp30)機能障害及びその生物学的用途
Document Type and Number:
Japanese Patent JP2011524743
Kind Code:
A
Abstract:
The present invention relates to a method of assessing a favorable or, on the contrary, an unfavorable prognosis of a cancer in the subject, which method comprises detecting the presence of a mutated Natural Cytotoxicity-triggering Receptor 3 (NCR3) nucleic acid, an abnormal relative amount of at least one particular Natural Killer p30 (NKp30) RNA transcript isoform, and/or an abnormal Natural Killer p30 (NKp30) expression or activity of at least one particular NKp30 protein isoform in a sample from the subject, the presence of mutated NCR3 nucleic acid, abnormal relative amount of at least one particular NKp30 RNA transcript isoform, or abnormal expression or activity of at least one particular NKp30 protein isoform being indicative of the prognosis of cancer in the subject.
Inventors:
Zivogel, Laurence
Durae, Nikola
Durae, Nikola
Application Number:
JP2011512095A
Publication Date:
September 08, 2011
Filing Date:
June 02, 2009
Export Citation:
Assignee:
INSTITUT GUSTAVE ROUSSY
INSERM(INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
INSERM(INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
International Classes:
C12N15/09; A61K31/7088; A61K31/7105; A61K35/12; A61K35/28; A61K38/00; A61K45/00; A61K45/06; A61K48/00; A61P35/00; A61P35/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/574
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito