Title:
神経保護ポリフェノールアナログ
Document Type and Number:
Japanese Patent JP2014524426
Kind Code:
A
Abstract:
The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzheimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.
Inventors:
Schubert and David R.
Marc and Pamela Ey.
チルタ and chandoo ラモーリ
Marc and Pamela Ey.
チルタ and chandoo ラモーリ
Application Number:
JP2014525170A
Publication Date:
September 22, 2014
Filing Date:
August 10, 2012
Export Citation:
Assignee:
Salk Institute Fau Biological スタディーズ
International Classes:
C07D215/22; A61K31/122; A61K31/343; A61K31/37; A61K31/40; A61K31/4025; A61K31/47; A61K38/00; A61K38/43; A61K38/48; A61K45/00; A61P3/10; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07C49/835; C07C49/84; C07D307/83; C07D311/30; C07D311/92
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto