Title:
神経系疾患治療剤
Document Type and Number:
Japanese Patent JP6650650
Kind Code:
B2
Abstract:
An object is to provide a drug which is useful in treating a nervous system disease. A drug containing vitamin B12as an active ingredient according to the present invention has an M2 macrophage/microglia induction promoting effect, an M1 macrophage/microglia induction inhibiting effect, a nerve regeneration promoting effect, and the like and is very useful as a therapeutic agent for a nervous system disease, and particularly useful as a therapeutic agent for a central nervous system disease such as cerebral infarction, dementia, or spinal cord injury.
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Inventors:
Hiroyuki Tanaka
Hideki Yoshikawa
Hideki Mochizuki
Murase Go
Ben Sasaki
Baba Kosuke
Tohru Iwahashi
Mitsuru Uchiki
Hideki Yoshikawa
Hideki Mochizuki
Murase Go
Ben Sasaki
Baba Kosuke
Tohru Iwahashi
Mitsuru Uchiki
Application Number:
JP2019554940A
Publication Date:
February 19, 2020
Filing Date:
December 20, 2018
Export Citation:
Assignee:
National University Corporation Osaka University
Nippon Organ Pharmaceutical Co., Ltd.
Nippon Organ Pharmaceutical Co., Ltd.
International Classes:
A61K31/714; A61K9/08; A61P7/02; A61P9/00; A61P9/10; A61P25/00; A61P25/28
Domestic Patent References:
| JP2014511830A |
Foreign References:
| CN102772407A | ||||
| CN102631667A | ||||
| CN104688763A | ||||
| CN1261535A |
Other References:
SUZUKI, Koji et al.,Electrospun nanofiber sheets incorporating methylcobalamin promote nerve regeneration and functional,Acta Biomaterialia,2017年 4月15日,VOL. 53,p. 250-259
WATANABE Tetsuya et al.,Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy,Journal of the Neurological Sciences,1994年 4月,VOL. 122, ISSUE 2,p. 140-143
YAMAZAKI, Kazuto et al.,Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior,Neuroscience Letters,1994年 3月28日,VOL. 170, NO. 1,p. 195-197
メチコバール錠,2014年 2月
市丸精一,脳血管障害性痴呆患者に対するメチルB12大量投与による治療の試み,臨牀と研究,1989年 1月,第66巻第1号,p. 310-316
WATANABE Tetsuya et al.,Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy,Journal of the Neurological Sciences,1994年 4月,VOL. 122, ISSUE 2,p. 140-143
YAMAZAKI, Kazuto et al.,Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior,Neuroscience Letters,1994年 3月28日,VOL. 170, NO. 1,p. 195-197
メチコバール錠,2014年 2月
市丸精一,脳血管障害性痴呆患者に対するメチルB12大量投与による治療の試み,臨牀と研究,1989年 1月,第66巻第1号,p. 310-316
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office