Neuroactive steroid, constituents, and those use

Japanese Patent JP6205362

B2

Compounds are provided according to Formula (I):and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v):and wherein L¹, L², L³, X¹, X², Y, R^Z4, R^Z5, R^Z6, n, R¹, R², R^3a, R^3b, R^4a, R^4b, R^6a, R^6b, R^7a, R^7b, R^11a, R^11b, R¹⁴, R¹⁷, R¹⁹, R²⁰, R^23a, R^23b, and R²⁴ are as defined herein, and pharmaceutical compositions thereof. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions in mammals.

Upasani, Ravindra Bee.
Harrison, Boyd Elle.
Ascou, Benny Sea. Junior
Gene Dodart, Cosmetics
Salituro, Francescogy.
Rovi Chow, Albert Jay.

JP2014529913A

September 27, 2017

September 07, 2012

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Sage Therapeutics, Incorporated

C07J9/00; A61K31/575; A61P9/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/36; A61P27/16; A61P43/00

JP8268917A
JP2005508368A
JP2002544137A
JP9507830A

FR2850023A1
US3079385

Journal of Pharmaceutical Sciences,1978年,67(12),1739-1743
Journal of Chemical Research,1977年,9,218
Russian Journal of Bioorganic Chemistry,2006年,32(6),586-594
Steroids,5(5),1965年,585-598
Liebigs Annalen der Chemie,1972年,758,89-110
Chemische Berichte,1965年,98(7),2361-2375
Journal of Medicinal Chemistry,1978年,21(10),1025-1029
The Journal of Neuroscience,2013年,33(44),17290-17300
Bioorganic & Medicinal Chemistry,2013年,21,5297-5309

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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