Title:
神経変性疾患治療薬
Document Type and Number:
Japanese Patent JP5145563
Kind Code:
B2
Abstract:
[PROBLEMS] To provide a neuronal cell death inhibitor and a therapeutic agent for a neurodegenerative disease, particularly Parkinson's disease. [MEANS FOR SOLVING PROBLEMS] It is known that DJ-1 protein is involved in Parkinson's disease and is capable of inhibiting neuronal cell death caused by oxidative stress. Based on this knowledge, screening is made for a low molecular weight molecule capable of binding to an active site of DJ-1 protein (i.e., a region around a cysteine residue at position-106) using an analysis softwear FastDock (Fujitsu Ltd.). When various tests are made using candidate low molecular weight compounds each having a binding energy of -60 kcal/mol or lower, these compounds show a therapeutic effect on a neurodegenerative disease.
Inventors:
Hiroyoshi Ariga
Application Number:
JP2007546418A
Publication Date:
February 20, 2013
Filing Date:
November 17, 2006
Export Citation:
Assignee:
National University Corporation Hokkaido University
International Classes:
A61K31/52; A61K31/36; A61K31/7072; A61K31/7076; A61K38/00; A61P25/16; A61P25/28; C07D317/64; C07D519/00; C07H19/04; C07K5/08; C07D473/34
Domestic Patent References:
| JPS56102794A | 1981-08-17 | |||
| JPH0338553A | 1991-02-19 | |||
| JPH0245425A | 1990-02-15 | |||
| JPH04290895A | 1992-10-15 |
Foreign References:
| GB1308259B |
Attorney, Agent or Firm:
Kiyoji Kuzuwa