ニューロンエキソサイトーシス抑制ペプチド - ビーシーエヌペプチデス，エス．アー．

Title:

ニューロンエキソサイトーシス抑制ペプチド

Document Type and Number:

Japanese Patent JP5647413

Kind Code:

B2

Abstract:

The invention relates to peptides of general formula (I): R 1 -AA-R 2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R 2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R 1 is H or acetyl, R 2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.

Inventors:

カレノセライマ，クリスチナ
ポンサチオビオルス，ベルタ
バンデンネスト，ウィム
フェルナンデスカルネアド，ヒメナ
フェレルマンチエル，アントニオ
セブリアンプチェ，ホアン
アルミニャナドメネチ，ヌリア

Application Number:

JP2009533889A

Publication Date:

December 24, 2014

Filing Date:

October 24, 2007

Export Citation:

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Assignee:

ビーシーエヌペプチデス，エス．アー．

International Classes:

C07K7/06; A61K8/64; A61K9/127; A61K9/50; A61K9/51; A61K38/00; A61P17/00; A61P21/00; A61P43/00; A61Q1/00; C07K1/04

Attorney, Agent or Firm:

Yuriko Hamada
Kenji Kitajima
Hironori Honda

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