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Title:
NEUROPROTECTIVE SUBSTANCE CU39, ITS PRODUCTION AND USE
Document Type and Number:
Japanese Patent JPH09295976
Kind Code:
A
Abstract:

To obtain the subject new compound having inhibitory activity against glutamic acid toxicity, and useful as a neurocyte protective agent, cerebrocyte degeneration inhibitor or cerebrocyte necrosis inhibitor.

This new compound cu39 (salt) is shown by the formula, and obtained by culturing cu39-productive bacteria belonging to the genus Streptomyces: Streptomyces sp. cu39 strain (FERM BP-482). This compound has the following physicochemical properties: appearance: yellow powder; melting point : 184-186°C; solubility: readily soluble to ethyl acetate, acetone, chloroform, methanol, ethanol; Rf number: 0.2 (CHCl3: MeOH=50:1); HRFAB-MS spectrum: 379, 1182 (calculated); specific rotatory power:[α]21D, =2.5 (c=0.02, MeOH); and molecular formula: C22H18O6. The dose of the cu39 is 0.1-100mg per day per adult.


Inventors:
SETO HARUO
ARAYA KAZUO
Application Number:
JP11080696A
Publication Date:
November 18, 1997
Filing Date:
May 01, 1996
Export Citation:
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Assignee:
KIRIN BREWERY
International Classes:
C12P17/06; A61K31/35; A61K31/352; A61P25/28; C07D311/78; C12R1/465; (IPC1-7): C07D311/78; A61K31/35; C12P17/06