Title:
神経変性障害の予防及び処置のための中性エンドペプチダーゼ(NEP)及びヒト可溶性エンドペプチダーゼ(HSEP)阻害剤
Document Type and Number:
Japanese Patent JP4951350
Kind Code:
B2
Abstract:
The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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Inventors:
Weske, Michael
Toulski, Rekoslau Ay
Iconomedo, Resantai
Tweeter, dater
Toulski, Rekoslau Ay
Iconomedo, Resantai
Tweeter, dater
Application Number:
JP2006548311A
Publication Date:
June 13, 2012
Filing Date:
January 10, 2005
Export Citation:
Assignee:
Abbott Healthcare Products B.V.
International Classes:
A61K31/55; A61P25/00; A61P25/28; A61K31/661; A61P25/14; A61P25/16; C07D223/16
Domestic Patent References:
| JP8269011A | ||||
| JP11292886A | ||||
| JP2002513032A |
Foreign References:
| WO2002094176A1 |
Other References:
TABRIZCHI R,CURRENT OPINION IN INVESTIGATIGATIONAL DRUGS,米国,PHARMAPRESS,2003年 3月,V4 N3,P329-332
PARK, L.,Phosphoramidon-sensitive endothelin-converting enzymes modulate cerebral blood flow and neural damage of hypoxic rats,Neuroscience Letters,2001年,301(2),p. 95-98
PARK, L.,Phosphoramidon-sensitive endothelin-converting enzymes modulate cerebral blood flow and neural damage of hypoxic rats,Neuroscience Letters,2001年,301(2),p. 95-98
Attorney, Agent or Firm:
Patent business corporation Odashima patent office