新規1-フェニルアルカノン5-HT▲4▼レセプターリガンド類

Title:

新規1-フェニルアルカノン5-HT▲4▼レセプターリガンド類

Document Type and Number:

Japanese Patent JP3935199

Kind Code:

B2

Abstract:

The present invention relates to novel 5-HT4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C1-4)alkyloxy or phenyl(C1-4)alkyloxy and optionally substituted at its 3-position with (C1-4)alkyloxy or substituted at its 2- and 3-positions together with methylenedioxy or ethylenedioxy and the highest numbered carbon of the (C2-6)alkan-1-one is substituted with di(C1-4)alkylamino, morpholin-1-yl or pyrrolidin-1-yl or optionally substituted piperidin-1-yl, piperidin-4-yl, azacyclohept-1-yl, azabicyclo[2.2.1]hept-3-yl, azabicylo[2.2.2]oct-3-yl or azabicylo[3.2.2]non-3-yl; and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers and methods of using and making such derivatives.

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Inventors:

Clark, Robin Dee
Eglen, Richard
Jahangir, Aram
Miller, Aaron Bee
Gardner, John Oh

Application Number:

JP50083695A

Publication Date:

June 20, 2007

Filing Date:

May 25, 1994

Export Citation:

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Assignee:

Syntex (USA), Inc.

International Classes:

C07C225/22; A61K31/136; C07D295/10; A61K31/335; A61K31/357; A61K31/36; A61K31/40; A61K31/4409; A61K31/4418; A61K31/4425; A61K31/443; A61K31/445; A61K31/4465; A61K31/451; A61P1/00; A61P9/00; A61P13/00; A61P13/02; A61P15/00; A61P25/00; A61P43/00; C07C239/16; C07C259/10; C07D207/09; C07D211/14; C07D211/20; C07D211/32; C07D211/34; C07D211/46; C07D211/58; C07D211/62; C07D213/46; C07D295/03; C07D295/108; C07D317/58; C07D317/66; C07D319/18; C07D405/06; C07D487/08

Domestic Patent References:

JP61161282A
JP49094640A
JP48017266B1
JP57181073A
JP55113715A
JP4364164A

Foreign References:

GB1218163A

Other References:

Bioorganic & Medicinal Chemistry Letters, 1992年,2(5),p.461-466
Bioorganic & Medicinal Chemistry Letters, 1994年,4(20),p.2481-2484
Bioorganic & Medicinal Chemistry Letters, 1994年,4(20),p.2477-2480

Attorney, Agent or Firm:

Aoyama Aoi
Kyousei Tamura
Shoji Nakajima

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