Title:
【発明の名称】新規な11-アリールエストラン及び11-アリールプレグナン誘導体
Document Type and Number:
Japanese Patent JP2655676
Kind Code:
B2
Abstract:
The present invention is concerned with 11-aryloestrane and 11-arylpregnane derivatives, characterized in that these derivatives have the following structure: wherein R1 is an aryl group with an -N- @ group as substituent, X and Y each being separat H or a (1- 4C) hydrocarbon radical or together a (2-6 C) hydrocarbon radical; R2 is an alkyl group containing 1-4 carbon atoms; R3 is H, OH, a saturated or unsaturated hydrocarbon radical containing 1-8 carbon atoms, at least provided with a hydroxyl, oxo, halogen, azido or nitrile group; an acyloxy or an alkoxy group; R4 is a hydroxyl, an acyloxy or an alkoxy group or an acyl group optionally provided with a hydroxyl, alkoxy, acyloxy or halogen group; or R3 and R4 together form a ring system; and R5 is a hydrocarbon group containing 1-4 carbon atoms, and further with processes for the preparation of these compounds and with pharmaceutical preparations comprising these compounds. The compounds according to the present invention exhibit antiprogestin activity.
Inventors:
MARINUSU BERUNARUDO GURUUN
HENDORITSUKU PAURU DE YONGU
HENDORITSUKU PAURU DE YONGU
Application Number:
JP10001088A
Publication Date:
September 24, 1997
Filing Date:
April 22, 1988
Export Citation:
Assignee:
AKUZO NOOBERU NV
International Classes:
A61K31/565; A61K31/57; A61K31/585; A61P5/38; C07J1/00; C07J21/00; C07J41/00; C07J71/00; (IPC1-7): C07J41/00; A61K31/565; A61K31/57
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)