NEW 17-(3-IMINO-2-ALKYLPROPENYL)-5BETA,14BETA-ANDROSTANE DERIVATIVE ACTIVE ON CARDIOVASCULAR SYSTEM, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Japanese Patent JP3899136

B2

PROBLEM TO BE SOLVED: To obtain the subject new steroid compound, a specific 17-(3-imino-2- alkylpropenyl)-5β,14β-androstane derivative, active on the cardiovascular system and usable in the treatment of cardiovascular disorders such as heart failure and hypertension.
SOLUTION: This new androstane derivative is shown by formula I {wavy line means α- or β-configuration; double bond represents E-configuration; R1 is H or (NR5R6)2-4C alkyl (R5 and R6 are each H, a 1-6C alkyl, or joined together with N into a 5- or 6-membered saturated heterocycle which optionally contains O and N); R2 is H or OH; R3 is methyl, ethyl or n-propyl; R4 is a group of formula II [R7 to R9 are each H, methyl or (NR5R6)2-4C alkyl], OR10 (R10 is the same kind as R7) or the like} and useful in the treatment of cardiovascular disorders such as heart failure and hypertension. This compound is obtained by condensation reaction of an aldehyde derivative of formula III with a compound of formula II and a compound of the formula, H2NOR10.

Alberto Ceri
Giuseppe Bianchi
Patrizia Ferrari
Clown meloni
Maria Louisa Quadri

JP31066995A

March 28, 2007

November 29, 1995

Click for automatic bibliography generation  

SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI

A61K31/56; A61K31/575; A61K31/58; C07J41/00; A61P9/00; A61P9/04; A61P9/12; C07J43/00; (IPC1-7): C07J41/00; A61K31/575; //A61K31/58; C07J43/00

JP7330792A
JP7267983A
JP6184187A
JP6184188A

J. Med. Chem.,1978年,Vol.21, No.3,pp 284-288

Aoyama Aoi
Eiji Minazaki

Previous Patent: INK DUCTOR IN PRINTING PRESS

Next Patent: MODEL PRODUCTION DEVICE AND ITS STORAGE MEDIUM