新規4-フェニルアミノ-ベンズアルドオキシム誘導体並びにそのMEK阻害剤としての使用

Japanese Patent JP4931419

B2

A compound of the present invention, or a pharmaceutically acceptable salt thereof is indicated by formula (1) below: wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, R 8 , and R 9 have the same meanings as R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, R 8 , and R 9 in the specification.

WO/2006/134469	METHODS OF PREPARING MEK INHIBITOR
WO/1996/019441	METHOD FOR PREPARING DESFERRIOXAMINE B AND HOMOLOGS THEREOF
WO/2003/075836	CATHEPSIN CYSTEINE PROTEASE INHIBITORS

Yoshiaki Isshiki
Yasunori Kawauchi
Kazuo Hattori
Nobuo Shinma
Miwa Masataka
Naoto Inagaki
Hitoshi Iikura
Yasuaki Matsubara

JP2005514046A

May 16, 2012

September 16, 2004

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Chugai Pharmaceutical Co., Ltd.

C07C259/10; A61K31/166; A61K31/18; A61K31/40; A61K31/4015; A61K31/4164; A61K31/4166; A61K31/4409; A61K31/445; A61K31/4453; A61K31/5375; A61P1/00; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P15/00; A61P17/06; A61P19/02; A61P19/04; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07C63/74; C07C229/58; C07C271/16; C07C311/04; C07C317/18; C07C323/12; C07D207/08; C07D207/27; C07D211/46; C07D213/30; C07D233/32; C07D233/34; C07D233/54; C07D233/64; C07D263/32; C07D295/08; C07D295/088; C07D295/155; C07F7/10; C07F7/18; C07D207/26

JP2002332247A	2002-11-22
JP2002534510A	2002-10-15
JP2002534491A	2002-10-15
JP2003527379A	2003-09-16
JPS59210046A	1984-11-28
JPS4861448A	1973-08-28
JPS4615935B1	1971-04-30
JP2007504241A	2007-03-01

WO2003051877A1	2003-06-26
US2967187A	1961-01-03

Hatsushi Shimizu
Koichi Niimi

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