Title:
新規な5-置換された7-アミノ[1,3]チアゾロ[4,5-D]ピリミジン誘導体
Document Type and Number:
Japanese Patent JP5165553
Kind Code:
B2
Abstract:
There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
Inventors:
Gunnar Nordval
Colin Ray
Tobias Rain
Daniel Zone
Colin Ray
Tobias Rain
Daniel Zone
Application Number:
JP2008505262A
Publication Date:
March 21, 2013
Filing Date:
April 03, 2006
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D513/04; A61K31/519; A61P9/10; A61P11/00; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P43/00
Domestic Patent References:
| JP2007507494A | ||||
| JP2008535834A | ||||
| JP2008524186A | ||||
| JP2003522191A | ||||
| JP2002522544A | ||||
| JP2003511384A | ||||
| JP2003522192A |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi