Title:
新規6-(4-フエニルブトキシ)ヘキシルアミン誘導体およびサルメテロールの製法
Document Type and Number:
Japanese Patent JP3786834
Kind Code:
B2
Abstract:
The present invention refers to new derivatives of the 6-(4-phenylbutoxy)hexylamine of the general formula (I): wherein: R1 is CHO or CHOR3OR4, where R3 and R4 independently are C1-C6 alkyl, aralkyl, or they form 5 or 6 membered cyclic acetals; and R2 is H, benzyl or an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group; and to a process for its obtention. The invention also refers to a new process for obtaining Salmeterol or its pharmaceutically acceptable salts, characterised in that reaction of an organometallic compound of the general formula (13) is carried out in an inert solvent at low temperature with a synthetic intermediate of the general formula (I), wherein R1 is CHO, and R2 is an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group.
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Inventors:
Jordi, Bessa, Bellmund
Pele, Dalmases, Verhoan
Francisco, Marquis, Olondris
Pele, Dalmases, Verhoan
Francisco, Marquis, Olondris
Application Number:
JP2000572184A
Publication Date:
June 14, 2006
Filing Date:
September 20, 1999
Export Citation:
Assignee:
Vita Scientifica
International Classes:
C07C217/28; C07B61/00; C07C213/02; C07C213/08; C07C217/40; C07C217/42; C07C221/00; C07C223/02; C07C271/16; C07C271/18; C07D319/08; C07C217/10
Domestic Patent References:
| JP63264443A | ||||
| JP3133946A |