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Title:
核酸のデリバリーのための新規脂質および脂質ナノ粒子製剤
Document Type and Number:
Japanese Patent JP7030690
Kind Code:
B2
Abstract:
Compounds are provided having the following structure:or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

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Inventors:
Stephen M Ansel
Shinyao Do
Application Number:
JP2018521205A
Publication Date:
March 07, 2022
Filing Date:
October 28, 2016
Export Citation:
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Assignee:
Acuitas Therapeutics Inc.
International Classes:
C07C219/06; A61K9/127; A61K9/14; A61K9/50; A61K31/7105; A61K47/10; A61K47/18; A61K47/24; A61K47/28; A61K47/54; C07C229/16; C07C233/36; C07C255/24
Domestic Patent References:
JP2001338416A
JP2013095755A
JP2018532721A
JP2019519511A
Foreign References:
WO2011136368A1
US20020062044
Other References:
Journal of the American Chemical Sciety,2007年,129(37),11408-11420
Attorney, Agent or Firm:
Yamato Kento
Sei Morimoto
Nobuhiko Akiyama



 
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