Title:
ポリペプチド抗原をコードしている新規ストレプトコッカスニューモニアエオープンリーディングフレームおよびその使用
Document Type and Number:
Japanese Patent JP2005501518
Kind Code:
A
Abstract:
The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae. In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by Streptococcus pneumoniae. In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by Streptococcus pneumoniae.
Inventors:
Robert John Zagerski
Amy Waddams Mashi
Bruce Arthur Green
Fat Narayan Chakrabalti
David Parish Russell
Joseph Lawrence Wouters
Amy Waddams Mashi
Bruce Arthur Green
Fat Narayan Chakrabalti
David Parish Russell
Joseph Lawrence Wouters
Application Number:
JP2002582194A
Publication Date:
January 20, 2005
Filing Date:
April 12, 2002
Export Citation:
Assignee:
Wyeth Holdings Corporation
International Classes:
G01N33/53; A61K39/09; A61K48/00; A61P31/04; A61P37/04; C07K14/315; C07K16/12; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/68; G01N33/569; G01N37/00; A61K38/00; A61K39/00; (IPC1-7): C12N15/09; A61K39/09; A61K48/00; A61P31/04; A61P37/04; C07K14/315; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/68; G01N33/53; G01N33/569; G01N37/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga