NEW ACTIVATION OF PROTHROMBIN AND PRODUCTION OF THROMBIN ON BASIS OF THE METHOD

Title:

NEW ACTIVATION OF PROTHROMBIN AND PRODUCTION OF THROMBIN ON BASIS OF THE METHOD

Document Type and Number:

Japanese Patent JPH11228443

Kind Code:

A

Abstract:

To produce the subject compound on an industrial scale on the basis of a means capable of achieving the conversion of an easily available raw material into thrombin in the absence of thromboplastin by treating a prothrombin-containing aqueous solution with glycerol.

This method for activating prothrombin into thrombin comprises treating a prothrombin-containing aqueous solution with glycerol preferably in the presence of a calcium salt (for example, calcium chloride, calcium hydroxide or calcium acetate) preferably at 4-37°C, more preferably 10-25°X. The prothrombin-containing aqueous solution is preferably 'a prothrombin complex' or 'an aqueous solution containing the prothrombin and the blood coagulation factor X as main components', and is obtained, for example, by a method comprising treating plasma with an anion exchanger to prepare the prothrombin complex.

Inventors:

KAMIMURA KOUICHIROU
KAETSU HIROSHI
MIZUGUCHI JUN
HAMAMOTO TAKAYOSHI

Application Number:

JP4131898A

Publication Date:

August 24, 1999

Filing Date:

February 07, 1998

Export Citation:

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Assignee:

CHEMO SERO THERAPEUT RES INST

International Classes:

C12N9/74; A61K38/43; (IPC1-7): A61K38/43; C12N9/74

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