NEW ALKYLATED (HETERO)CYCLIC COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Title:

NEW ALKYLATED (HETERO)CYCLIC COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Document Type and Number:

Japanese Patent JPH08239353

Kind Code:

A

Abstract:

To obtain a new compound having strong affinity with a melatonin effecting receptor and useful for treating seasonal melancholy, dysgryphia, etc.,

A compound of formula I (R1 is an alkyl or the like; A forms a cyclic ring such as naphthalene ring, benzothiophen ring, indole ring, etc., together with the benzene ring; R2 is H or an alkyl; R3 is an acyl, a carbamoyl or the like) and its enanthiomer or diastereomer, for example, N-[2-(5- ethylbenzothiophen-3-yl)ethyl]acetamide. The compound of formula I is obtained by reacting a compound of formula II with formic acid, a compound of formula III (R41 is an alkyl; Hal is a halogen), etc. The compound of formula I exhibits a remarkable activity for the central nervous system, has an immunoregulatory characteristic and an ovulation-inhibiting characteristic, and is further useful for treating cancers. The compound of formula I is administered at a daily dose of 0.1 mg-1 g.

Inventors:

LESIEUR DANIEL (FR)
FOURMAINTRAUX ERIC (FR)
DEPREUX PATRICK (FR)
DELAGRANGE PHILIPPE (FR)
RENARD PIERRE (FR)
GUARDIOLA-LEMAITRE BEATRICE (FR)

Application Number:

JP272196A

Publication Date:

September 17, 1996

Filing Date:

January 11, 1996

Export Citation:

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Assignee:

ADIR (FR)

International Classes:

A61K31/165; A61K31/17; A61K31/18; A61K31/34; A61K31/343; A61K31/40; A61K31/403; A61K31/404; A61P3/00; A61P3/04; A61P9/00; A61P9/08; A61P9/10; A61P25/20; A61P25/24; A61P25/26; A61P43/00; C07C231/02; C07C233/02; C07C233/05; C07C233/08; C07C233/09; C07C233/58; C07C273/02; C07C275/24; C07C275/26; C07C303/38; C07C311/03; C07C311/10; C07C311/11; C07C327/38; C07C335/12; C07C335/14; C07D209/14; C07D307/81; C07D333/58; (IPC1-7): C07C233/02; A61K31/165; A61K31/17; A61K31/18; A61K31/40; C07C231/02; C07C233/05; C07C233/08; C07C233/09; C07C233/58; C07C273/02; C07C275/24; C07C275/26; C07C303/38; C07C311/03; C07C311/10; C07C311/11; C07C327/38; C07C335/12; C07C335/14; C07D209/14; C07D333/58

Attorney, Agent or Firm:

Hajime Tsukuni (2 outside)

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