Title:
NEW ALKYNYL DERIVATIVE AS MODULATOR OF METABOTROPIC GLUTAMIC ACID RECEPTOR
Document Type and Number:
Japanese Patent JP2012051937
Kind Code:
A
Abstract:
To provide a new alkynyl derivative as the modulator of a metabotropic glutamic acid receptor.
This invention relates to new compounds of formula (I), wherein, W, n, X and W' are defined by description. The compounds are the modulators of metabotropic glutamic acid receptors-subtype 5 ("mGluR5"), and are useful naturally for the treatment of central nervous system disorders as well as for the treatment of other disorders modulated by the mGluR5 receptors.
Inventors:
BESSIS ANNE-SOPHIE
BOLEA CHRISTELLE
BONNET BEATRICE
EPPING-JORDAN MARK
POIRIER NICHOLAS
POLI SONIA-MARIA
ROCHER JEAN-PHILIPPE
THOLLON YVES
BOLEA CHRISTELLE
BONNET BEATRICE
EPPING-JORDAN MARK
POIRIER NICHOLAS
POLI SONIA-MARIA
ROCHER JEAN-PHILIPPE
THOLLON YVES
Application Number:
JP2011251754A
Publication Date:
March 15, 2012
Filing Date:
November 17, 2011
Export Citation:
Assignee:
ADDEX PHARMA SA
International Classes:
C07D213/26; A61K31/4035; A61K31/4164; A61K31/4192; A61K31/4196; A61K31/422; A61K31/423; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/4402; A61K31/4412; A61K31/4427; A61K31/4439; A61K31/444; A61K31/47; A61K31/4709; A61K31/502; A61K31/505; A61K31/506; A61P1/04; A61P3/04; A61P25/00; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/36; A61P29/00; A61P43/00; C07D213/30; C07D213/40; C07D213/42; C07D213/55; C07D213/56; C07D213/64; C07D215/04; C07D215/06; C07D233/54; C07D233/58; C07D239/26; C07D239/30; C07D263/56; C07D277/20; C07D277/22; C07D277/30; C07D277/64; C07D401/06; C07D403/06; C07D413/06; C07D413/12; C07D417/06; C07D417/12; C07D471/04; C07D498/04; C07B61/00
Domestic Patent References:
| JP2003535858A | 2003-12-02 | |||
| JP2008502674A | 2008-01-31 |
Foreign References:
| WO2003104206A2 | 2003-12-18 | |||
| WO1992005159A1 | 1992-04-02 | |||
| WO2005097777A1 | 2005-10-20 | |||
| WO2004078729A1 | 2004-09-16 | |||
| WO2001016121A1 | 2001-03-08 | |||
| WO2004078728A1 | 2004-09-16 | |||
| WO2005044265A1 | 2005-05-19 | |||
| WO2005044266A1 | 2005-05-19 |
Other References:
JPN6011024501; Ｊ． Ｃｈｅｍ． Ｓｏｃ．， Ｐｅｒｋｉｎ Ｔｒａｎｓ．１ , 2001, ９７８-９８４
JPN6011024502; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． ６, 1998, ５２３-５３３
JPN6011024502; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． ６, 1998, ５２３-５３３
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura