New alternative androgen receptor modulator

Title:

New alternative androgen receptor modulator

Document Type and Number:

Japanese Patent JP6039100

Kind Code:

B2

Abstract:

The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or —CR0—, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is —CRe—, or, —N—, where Re is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1-C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1-C6 linear or branched chain alkyl, etc.; R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; Q is —CO—, —(CH2)q—, —(CHRs)q—, or —(CRsRt)q—, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.

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Inventors:

James Thomas Anderson
Eugene Lvovich Piatnitzky Cheklar
Edmund Elle Ellsworth
Bruce Kip Ericsson
Adam Matthew Gilbert
Anthony P. Ricketts
David P. Thompson
Raymond Jal Anwara
Patrick Robert Verhost

Application Number:

JP2015544586A

Publication Date:

December 07, 2016

Filing Date:

November 25, 2013

Export Citation:

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Assignee:

Pfizer Inc.

International Classes:

C07D217/26; A61K31/472; A61K31/4725; A61K31/541; A61P1/14; A61P3/02; A61P3/04; A61P5/00; A61P7/00; A61P7/06; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P25/28; A61P43/00; C07D285/10; C07D401/04; C07D417/04

Domestic Patent References:

JP2004091486A

Foreign References:

WO2004110978A1
WO2009082437A1
WO2009105214A1
WO2005115361A1

Other References:

MANFREDI M. C. et al.,Bioorg. Med. Chem. Lett.,2007年,Vol.17,p.4487-90

Attorney, Agent or Firm:

Noh four
Junko Miyazawa
Maki Sato
Tatsuta Miyuki

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