Title:
新規アミド誘導体およびその医薬としての用途
Document Type and Number:
Japanese Patent JP4751567
Kind Code:
B2
Abstract:
The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a Äe.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the likeÜ. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.
Inventors:
Koji Nakamura
Takao Kamabori
Masatake Ishibuchi
Youichi Naka
Hiroshi Sumika
Katsuhiko Ito
Takao Kamabori
Masatake Ishibuchi
Youichi Naka
Hiroshi Sumika
Katsuhiko Ito
Application Number:
JP2002526757A
Publication Date:
August 17, 2011
Filing Date:
September 14, 2001
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07C233/58; A61K31/167; A61K31/275; A61K31/351; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/382; A61K31/40; A61K31/415; A61K31/4155; A61K31/4164; A61K31/425; A61K31/426; A61K31/429; A61K31/44; A61K31/4433; A61K31/4439; A61K31/444; A61K31/4453; A61K31/4465; A61K31/4545; A61K31/4704; A61K31/5375; A61K31/5377; A61P9/00; A61P9/10; A61P11/00; A61P17/06; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07C233/59; C07C233/60; C07C233/61; C07C233/62; C07C233/63; C07C233/88; C07C235/40; C07C235/82; C07C255/29; C07C255/60; C07C317/32; C07C317/40; C07C321/28; C07C323/40; C07C327/46; C07D207/06; C07D211/14; C07D213/40; C07D213/64; C07D213/65; C07D213/69; C07D213/74; C07D213/75; C07D215/50; C07D231/12; C07D233/61; C07D277/28; C07D295/13; C07D295/135; C07D295/18; C07D295/185; C07D309/12; C07D311/04; C07D311/58; C07D311/64; C07D311/66; C07D317/46; C07D317/58; C07D317/66; C07D319/18; C07D333/20; C07D333/36; C07D335/06; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D409/06; C07D409/14; C07D417/12; C07D417/14; C07D495/04; C07D513/04; C07D521/00
Domestic Patent References:
| JP2000083662A | 2000-03-28 | |||
| JPH05294960A | 1993-11-09 | |||
| JPS61109767A | 1986-05-28 |
Foreign References:
| US5491152A | 1996-02-13 | |||
| WO2002014265A1 | 2002-02-21 |
Attorney, Agent or Firm:
Takashima Ichi