NEW ARYL (ALKYL) PROPYLAMIDE, ITS PRODUCTION AND MEDICINE COMPOSITION CONTAINING THE SAME

Japanese Patent JPH093016

A

To obtain the subject new compound as a strong ligand for a melatonin receptor, having an effective action on sleep disorder, etc., anxiolytic, antipsychotic and analgesic characteristics, useful for treating Parkinson's disease, etc.

This compound is shown by formula I {R1 is H, OH, a group of the formula R6 [R6 is a (substituted) (cyclo)alky, etc.], etc.; R1' is H, a halogen, R6, etc.; R2 is H or an alkyl; R3 is a group (Z) of the formula (C=X)-R4[R4 is H, a (substituted) alkyl, etc.; X is S or O], etc.; (n) is 0-3; A forms benzothiophene with an adjoining benzene and, when R4 is an alkyl or vinyl, R1 is H or methyl and R' is H, n is not 0}, its enantiomer, diastereomer or and acid addition salt to a base such as N-[3-(7-methoxy-1-naphthyl) propyl]acetamide. The compound of formula I in which R3 is Z is obtained by reacting a compound of formula II with a compound of formula III (Hal is a halogen) and, in case of need, further reacting the obtained compound with a vulcanizing agent.

DANIERU RUSHIYUURU
BUERONIKU REKUREERU
PATORITSUKU DOUPURIYU
FUIRITSUPU DOURAGURANJIYU
PIEERU RENAARU

JP13195096A

January 07, 1997

May 27, 1996

Click for automatic bibliography generation  

ADIR

A61K31/16; A61K31/165; A61K31/17; A61K31/34; A61K31/343; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61P25/00; A61P25/04; A61P25/18; A61P25/28; C07C231/02; C07C231/12; C07C233/05; C07C233/18; C07C233/19; C07C233/20; C07C233/25; C07C233/27; C07C233/31; C07C233/40; C07C233/60; C07C235/34; C07C273/18; C07C275/24; C07C309/68; C07C327/42; C07C327/46; C07C335/08; C07C335/10; C07C335/12; C07D209/14; C07D307/81; C07D333/58; (IPC1-7): C07C233/05; A61K31/16; A61K31/165; A61K31/17; A61K31/34; A61K31/38; A61K31/40; C07C231/02; C07C231/12; C07C233/18; C07C233/20; C07C233/25; C07C233/27; C07C233/31; C07C233/40; C07C233/60; C07C235/34; C07C273/18; C07C275/24; C07C309/68; C07C327/42; C07C327/46; C07C335/08; C07C335/10; C07C335/12; C07D209/14; C07D307/81; C07D333/58

JPS60139684A	1985-07-24
JPH04173777A	1992-06-22
JPH08134030A	1996-05-28

US3829411A	1974-08-13
US3759895A	1973-09-18
US3767659A	1973-10-23
US2991290A	1961-07-04

YAKUGAKU ZASSHI (1965), 85(1), 21-7, JPN4007010871, ISSN: 0000857500
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1959), 81, 3083-8, JPN4007010872, ISSN: 0000857501
GATTA,F.他, EDIZIONE　SCIENTIFICA, vol. V30 N1, JPN4007010867, 1975, pages 58 - 69, ISSN: 0000857496
MONATSHEFTE FUER CHEMIE (1952), 83, 1453-76, JPN4007010868, ISSN: 0000857497
JOURNAL OF THE INDIAN CHEMICAL SOCIETY (1989), 66(7), 484-6, JPN4007010869, ISSN: 0000857498
HELVETICA CHIMICA ACTA (1976), 59(8), 2704-10, JPN4007010870, ISSN: 0000857499

Hajime Tsukuni (2 outside)

Next Patent: N-SUBSTITUTED CIS-N-PROPENYL-ACETAMIDE AND ITS PRODUCTION