Title:
新規のバキュロウイルスベクター及び使用の方法
Document Type and Number:
Japanese Patent JP6535133
Kind Code:
B2
Abstract:
A recombinant baculovirus displaying on its envelop a fusion protein is disclosed. The fusion protein comprises a heterologous antigen, and a C-terminal region of baculovirus envelope GP64 protein, which has at least 100 amino acid residues in length and lacks a B12D5 binding epitope located within the central basic region of the GP64 protein. The genome of the recombinant baculovirus comprises a transgene encoding a fusion protein that comprises a signal peptide, the heterologous antigen, and the C-terminal region of the baculovirus envelope GP64 protein, in which the antigen is located between the signal peptide and the C-terminal region of the GP64 protein. Methods for eliciting an antigen-specific immunogenic response in a subject in need thereof are also disclosed.
Inventors:
Chan, Cheer-Jun
Liao, Yang-Chiu
Butterfly, way
Zhang, Xu-Kang
Liao, Yang-Chiu
Butterfly, way
Zhang, Xu-Kang
Application Number:
JP2018511354A
Publication Date:
June 26, 2019
Filing Date:
May 13, 2016
Export Citation:
Assignee:
REBER GENETICS CO., LTD.
International Classes:
C12N7/01; A61K35/76; A61K39/00; A61K39/12; A61K39/125; A61K39/135; A61K39/145; A61K39/15; A61K39/17; A61K39/187; A61K39/21; A61K39/215; A61K39/225; A61K39/23; A61K39/245; A61K39/265; A61K39/275; A61K39/29; A61P31/00; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P43/00; C12N5/10; C12N15/117; C12N15/34; C12N15/62; C12N15/866
Domestic Patent References:
| JP2014195411A | ||||
| JP2014505681A | ||||
| JP10509596A | ||||
| JP2014534202A | ||||
| JP10506902A |
Foreign References:
| WO2006011646A1 | ||||
| WO2011099541A1 | ||||
| WO2009009215A1 | ||||
| WO2003104453A1 | ||||
| US20050208066 |
Other References:
Eur. J. Biochem., 2002, Vol.269, p.4458-4467
Virology, 2006, Vol.352, p.427-437
Virology, 2006, Vol.352, p.427-437
Attorney, Agent or Firm:
sk patent corporation
Akihiko Okuno
Hiroyuki Ito
Akihiko Okuno
Hiroyuki Ito