Title:
新規ビシクロヌクレオシド類縁体
Document Type and Number:
Japanese Patent JP4151751
Kind Code:
B2
Abstract:
This invention provides novel bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability. The present invention is compounds of the following formula (1) or their pharmaceutically acceptable salts. R<1> represents a hydrogen atom or protecting group for a hydroxy group, R<2> represents an azido group or an optionally protected amino group or the like, B represents a purin-9-yl or a 2-oxo-1,2-dihydropyrimidin-1-yl group which are optionally substituted with substituents selected from alpha group shown below. ( alpha group> halogen atom, alkyl group having 1-6 carbon atoms, hydroxy group, mercapto group, amino group, and the like.
Inventors:
Takeshi Imanishi
Satoshi Kobiga
Satoshi Kobiga
Application Number:
JP2000218496A
Publication Date:
September 17, 2008
Filing Date:
July 19, 2000
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C07H19/06; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61K31/7076; A61K31/712; A61K31/7125; A61P31/18; C07H19/067; C07H19/16; C07H19/167; C07H21/00
Foreign References:
| WO1998039352A1 | ||||
| US5684143 |
Other References:
Tetrahedron Letters, 1999, No. 40, 6465―6468.
Attorney, Agent or Firm:
Kimiki Ishibashi
Toshiaki Yaguchi
Yuki Echigo
Toshiaki Yaguchi
Yuki Echigo