Title:
NEW BISPHOSPHINE COMPOUND USEFUL AS CATALYST FOR ASYMMETRIC REACTION
Document Type and Number:
Japanese Patent JP3862784
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new enantiometrically pure specific diphenylbisphosphine useful e.g. as a ligand of a metallic catalyst capable of performing asymmetric reaction, especially asymmetric hydrogenation reaction in high stereoselectivity.
SOLUTION: The objective compound is an enantiometrically pure new bisphosphine expressed by formula I [R is phenyl which may have 1-3 substituents such as OR1 (R1 is a 1-6C alkyl), R1, nitro, NH2, NHR1 or NR12, a 1-7C alkyl or a 3-7C cycloalkyl]. It is useful e.g. as a ligand of a metal complex as a catalyst for performing asymmetric reaction, especially asymmetric hydrogenation reaction in high stereoselectivity. The compound can be produced by metallizing 5-bromo-2-chloro-anisole, reacting with a substituted phosphinic acid chloride expressed by formula II, metallizing the 6-site of the product, iodinating by reacting with iodine, dimerizing the product to form a racemic compound and subjecting the compound to optical resolution by the crystallization together with an enantiometrically pure carboxylic acid.
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Inventors:
Christian laue
Georg Shredder
Dieter Arlut
Georg Shredder
Dieter Arlut
Application Number:
JP17544696A
Publication Date:
December 27, 2006
Filing Date:
June 17, 1996
Export Citation:
Assignee:
Bayer Aktiengesellschaft
International Classes:
C07B35/02; B01J31/18; C07B41/02; C07F9/50; C07B53/00; C07C51/36; C07C57/30; C07C67/31; C07C69/675; C07F9/53; C07F15/00; (IPC1-7): C07F9/53; B01J31/18; C07B35/02; C07B41/02; C07B53/00; C07C51/36; C07C57/30; C07C67/31; C07C69/675; C07F15/00; //C07M7:00
Domestic Patent References:
| JP3005492A | ||||
| JP59059697A | ||||
| JP7082282A |
Attorney, Agent or Firm:
Heikichi Odashima