Title:
新規なカンナビゲロール誘導体
Document Type and Number:
Japanese Patent JP6619349
Kind Code:
B2
Abstract:
The present invention relates to novel cannabigerol quinone derivatives of formula (I)
wherein R is the carbon atom of a linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl, or alcoxycarbonil groups; or wherein R is the nitrogen atom of a linear or branched group, represented by: alkylamino, arylamino, alkenylamino or alkynylamino groups; or, alternatively, R represents a bond between 2 molecules of formula (I) forming a dimer. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating PPARg-related diseases due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.
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| JPH08231389 | ANTI-DERMATITIC AGENT |
Inventors:
Appendino, Giovanni
Belido Caveyo de Alba, Maria Luz
Muñoz Blanco, Eduardo
Belido Caveyo de Alba, Maria Luz
Muñoz Blanco, Eduardo
Application Number:
JP2016553568A
Publication Date:
December 11, 2019
Filing Date:
February 12, 2015
Export Citation:
Assignee:
Emerald Health Pharmaceuticals, Incorporated
International Classes:
C07C50/30; A61K31/122; A61K31/133; A61K31/137; A61K31/215; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07C69/95; C07C225/28
Domestic Patent References:
| JP2013523623A |
Foreign References:
| WO2006009765A1 |
Other References:
Valerie Mahiou, Francois Roblot, Reynald Hocquemiller, and Andre Cave,New Prenylated Quinones from Peperomia Galioides,Journal of Natural Products,1996年,Vol. 59,pp.694-697
Xiao-Long Yang, Cheng Qin, Fei Wang, Ze-Jun Dong, and Ji-Kai Liu,A New Meroterpenoid Pigment from the Basidiomycete Albatrellus confluens,CHEMISTRY & BIODIVERSITY,2008年,Vol. 5,pp.484-489
A. de la Pena, R. Izaguirre, G. Banos, M. Viveros, R. G. Enriquez, and J. M. Fernandez-G,Effect of perezone, aminoperezone and their correspomding isomers isoperezone and isoaminoperezone upon in vitro platelet aggregation,Phytomedicine,2001年,Vol. 8, No. 6,pp.465-468
Xiao-Long Yang, Cheng Qin, Fei Wang, Ze-Jun Dong, and Ji-Kai Liu,A New Meroterpenoid Pigment from the Basidiomycete Albatrellus confluens,CHEMISTRY & BIODIVERSITY,2008年,Vol. 5,pp.484-489
A. de la Pena, R. Izaguirre, G. Banos, M. Viveros, R. G. Enriquez, and J. M. Fernandez-G,Effect of perezone, aminoperezone and their correspomding isomers isoperezone and isoaminoperezone upon in vitro platelet aggregation,Phytomedicine,2001年,Vol. 8, No. 6,pp.465-468
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei