Title:
多剤耐性のモディファイアーとしての新規カルバメートおよびウレア
Document Type and Number:
Japanese Patent JP4421680
Kind Code:
B2
Abstract:
The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also comprises pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of multi-drug resistance and for use in multi-drug resistant cancer therapy.
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Inventors:
Zel, robert edward
Harding, Matthew W.
Harding, Matthew W.
Application Number:
JP52523595A
Publication Date:
February 24, 2010
Filing Date:
March 23, 1995
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07C271/18; A61K31/4406; A61K31/4418; A61K31/445; A61K31/47; A61K31/535; A61P43/00; C07C279/10; C07C333/04; C07C335/06; C07D211/60; C07D213/30; C07D213/55; C07D401/12; C07D401/14
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Foreign References:
| WO1992021313A1 | ||||
| WO1992019593A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita