Title:
新規カルボン酸誘導体、その製造及びその使用
Document Type and Number:
Japanese Patent JP5700378
Kind Code:
B2
Abstract:
Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
Inventors:
Hartmut Reichers
Darkmar Klinge
Wilhelm Amberg
Andreas Kling
Stephan Muller
Ernst Baumann
Joachim Reinheimer
Uwe-Josef Vogelbacher
Wolfgang Wernet
Liliane Unger
Manfred Rashack
Darkmar Klinge
Wilhelm Amberg
Andreas Kling
Stephan Muller
Ernst Baumann
Joachim Reinheimer
Uwe-Josef Vogelbacher
Wolfgang Wernet
Liliane Unger
Manfred Rashack
Application Number:
JP2012019532A
Publication Date:
April 15, 2015
Filing Date:
February 01, 2012
Export Citation:
Assignee:
Abbey Deutschland G.M.B.H.
International Classes:
C07C69/003; C07D251/30; A61K31/505; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/08; A61P13/02; A61P15/00; A61P25/04; C07C59/125; C07C255/37; C07D239/26; C07D239/28; C07D239/34; C07D239/38; C07D239/60; C07D239/70; C07D239/96; C07D251/12; C07D251/26; C07D251/52; C07D403/06; C07D403/12; C07D405/12; C07D413/12; C07D417/12; C07D487/04; C07D491/04; C07D491/044; C07D491/048; C07D239/00; C07D257/02; C07D309/00
Domestic Patent References:
| JP3957748B2 | ||||
| JP4787184B2 | ||||
| JP4360887A | ||||
| JP5125058A | ||||
| JP2085262A |
Foreign References:
| WO1993025540A1 | ||||
| DE4335950A1 | ||||
| DE4313412A1 | ||||
| DE4313413A1 |
Other References:
Alois Furstner,Journal of Organometallic Chemistry,1987年,Vol.336, No.3,p.C33-C36
Tetsuo Sekiya et al.,Chemical & Pharmaceutical Bulletin,1983年,Vol.31, No.7,p.2254-2261
Sadatoshi Akabori et al.,Bulletin of the Chemical Society of Japan,1980年,Vol.53, No.5,p.1463-1464
Tetsuo Sekiya et al.,Chemical & Pharmaceutical Bulletin,1983年,Vol.31, No.7,p.2254-2261
Sadatoshi Akabori et al.,Bulletin of the Chemical Society of Japan,1980年,Vol.53, No.5,p.1463-1464
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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