Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NEW CATECHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME AND ITS USE
Document Type and Number:
Japanese Patent JP2008308494
Kind Code:
A
Abstract:

To provide a new compound having a COMT (catechol-O-methyl transferase)-inhibiting action.

Provided are the compound represented by general formula (I) [wherein, R1 and R2 are each H, a lower acyl, a lower alkoxycarbonyl, or the like; R3 is a lower alkoxycarbonyl, -C(O)NR11R12, -SO2NR11R12, a lower alkylsulfonyl, an arylsulfonyl, a lower acyl, or the like; R4, R5, R6, R7 and R8 are each H, a halogen, a lower alkyl, a halogenated lower alkyl, a lower alkoxy, or the like] or its pharmacologically acceptable salt, a medicinal composition containing the same, and their uses. The compound of the present invention is useful as an agent for treating or preventing Parkinson's disease and the like, because of having an excellent COMT-inhibiting action.


More Like This:
WO/1998/015528NOVEL DIARYLMETHYLENE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USES THEREOF
JPH06507439INDUSTRIAL APPLICABILITY: Crosslinked polarized polymers for nonlinear optical applications and methods for producing them.
Inventors:
ISHIKAWA TAKEHIRO
NISHIMURA TOSHIHIRO
INOUE HITOSHI
KOBAYASHI SATOKO
YOSHIDA MASAKO
TANAKA NOBUYUKI
Application Number:
JP2008126729A
Publication Date:
December 25, 2008
Filing Date:
May 14, 2008
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KISSEI PHARMACEUTICAL
International Classes:
C07C317/22; A61K31/10; A61K31/12; A61K31/166; A61K31/18; A61K31/24; A61K31/277; A61K31/39; A61K45/00; A61P43/00; C07C317/24; C07C317/46; C07D327/02; C07D327/06; A61P9/12; A61P25/16; A61P25/24



 
Previous Patent: NEW CATECHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF

Next Patent: NEW CATECHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME AND ITS USE