Title:
新規な陽イオン性ポリホスファゼン化合物、ポリホスファゼン−薬物コンジュゲート化合物およびその製造方法
Document Type and Number:
Japanese Patent JP6659021
Kind Code:
B2
Abstract:
The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.
Inventors:
SOHN, Youn Soo
Jun, Yong Jo
Avazi, Prakash Gouda
Jun, Yong Jo
Avazi, Prakash Gouda
Application Number:
JP2016575280A
Publication Date:
March 04, 2020
Filing Date:
March 13, 2015
Export Citation:
Assignee:
CNPHARM CO., LTD.
International Classes:
A61K47/59; A61K31/282; A61K31/337; A61K31/4745; A61K47/34; A61K47/60; A61P35/00; C08G65/335; C08G79/025; C08G81/00
Domestic Patent References:
| JP2006525224A | ||||
| JP2006089745A | ||||
| JP2003514938A |
Foreign References:
| US20130324490 | ||||
| US20070292384 | ||||
| WO2013016696A1 |
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda